Technology Request

Ref: 07 GB LDLT 0IKC

Date: 10/08/2007 16:31:14

Title: Methods for visualising pancreatic beta cells and measuring beta cell function

Abstract: A London-based global pharmaceutical company is seeking methods to directly measure and/or visualise pancreatic beta cells and measure their function. One potential method would be using PET scans with suitable ligands, but the company is also open to other possibilities. The company would utilise this technology for measuring drug effects for future diabetic treatments. They are seeking collaborative work with academic institutions and/or businesses that have such capabilities.

Description: A number of new treatments for diabetes (targeting PPAR (peroxisome proliferator-activated receptors)-gamma, DPP (dipeptidyl peptidase)-IV or GLP (Glucagon-like peptide)-1) have the potential to improve beta cell function. Currently beta cell function is imputed from a number of traditional biomarkers (such as insulin). A more direct assessment of beta cell function is required. Technical Specifications / Specific technical requirements: Techniques that allow direct evaluation of beta cell function in preclinical and clinical settings are required for early proof of concept in drug development on existing or new therapeutic targets.